Submit a preprint

232

Genetic Evidence for Geographic Structure within the Neanderthal Populationuse asterix (*) to get italics
Alan R. RogersPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"
2024
<p>PSMC estimates of Neanderthal effective population size (N&lt;sub&gt;e&lt;/sub&gt;)exhibit a roughly 5-fold decline across the most recent 20 ky before the death of each fossil. To explain this pattern, this article develops new theory relating genetic variation to geographic population structure and local extinction. It argues that the observed pattern results from subdivision and gene flow. If two haploid genomes are sampled from the same subpopulation, their recent ancestors are likely to be geographic neighbors and therefore coalesce rapidly. By contrast, remote ancestors are likely to be far apart, and their coalescent rate is lower. Consequently, N&lt;sub&gt;e&lt;/sub&gt; is larger in the distant past than in the recent past.</p> <p>New theoretical results show that modest rates of extinction cause substantial reductions in heterozygosity, Wright's F&lt;sub&gt;ST&lt;/sub&gt;, and N&lt;sub&gt;e&lt;/sub&gt;.</p>
You should fill this box only if you chose 'All or part of the results presented in this preprint are based on data'. URL must start with http:// or https://
You should fill this box only if you chose 'Scripts were used to obtain or analyze the results'. URL must start with http:// or https://
https://doi.org/10.17605/OSF.IO/T4N3CYou should fill this box only if you chose 'Codes have been used in this study'. URL must start with http:// or https://
effective population size; archaic hominins; geographic population structure; local extinction, Markov chains
NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).
Evolutionary Biology, Genetics and population Genetics
Guillaume Achaz suggested: Guillaume Achaz No need for them to be recommenders of PCI Math Comp Biol. Please do not suggest reviewers for whom there might be a conflict of interest. Reviewers are not allowed to review preprints written by close colleagues (with whom they have published in the last four years, with whom they have received joint funding in the last four years, or with whom they are currently writing a manuscript, or submitting a grant proposal), or by family members, friends, or anyone for whom bias might affect the nature of the review - see the code of conduct
e.g. John Doe [john@doe.com]
2023-10-17 18:06:38
Raquel Assis