PCI Math Comp Biol

232

Title *

Genetic Evidence for Geographic Structure within the Neanderthal Populationuse asterix (*) to get italics

Authors *

Alan R. RogersPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year *

2024

Picture *

Abstract *

PSMC estimates of Neanderthal effective population size (Ne)exhibit a roughly 5-fold decline across the most recent 20 ky before the death of each fossil. To explain this pattern, this article develops new theory relating genetic variation to geographic population structure and local extinction. It argues that the observed pattern results from subdivision and gene flow. If two haploid genomes are sampled from the same subpopulation, their recent ancestors are likely to be geographic neighbors and therefore coalesce rapidly. By contrast, remote ancestors are likely to be far apart, and their coalescent rate is lower. Consequently, Ne is larger in the distant past than in the recent past. New theoretical results show that modest rates of extinction cause substantial reductions in heterozygosity, Wright's FST, and Ne.

Indicate the full web address (DOI or URL) giving public access to these data (if you have any problems with the deposit of your data, please contact contact@mcb.peercommunityin.org). In case all raw data are included in the preprint, indicate the DOI or URL of the preprint. *

You should fill this box only if you chose 'All or part of the results presented in this preprint are based on data'. URL must start with http:// or https://

Indicate the full web address (DOI or URL) giving public access to these scripts (if you have any problems with the deposit of your scripts, please contact contact@mcb.peercommunityin.org). In case all raw scripts are included in the preprint, indicate the DOI or URL of the preprint. *

You should fill this box only if you chose 'Scripts were used to obtain or analyze the results'. URL must start with http:// or https://

Indicate the full web address (DOI, SWHID or URL) giving public access to these codes (if you have any problems with the deposit of your codes, please contact contact@mcb.peercommunityin.org). In case all raw codes are included in the preprint, indicate the DOI or URL of the preprint. *

https://doi.org/10.17605/OSF.IO/T4N3CYou should fill this box only if you chose 'Codes have been used in this study'. URL must start with http:// or https://

Keywords (optional)

effective population size; archaic hominins; geographic population structure; local extinction, Markov chains

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields *

Evolutionary Biology, Genetics and population Genetics

Suggested reviewers - Suggest up to 10 reviewers (provide names and Email addresses). (Optional)

Guillaume Achaz suggested: Guillaume Achaz

e.g. John Doe john@doe.com

No need for them to be recommenders of PCI Math Comp Biol. Please do not suggest reviewers for whom there might be a conflict of interest. Reviewers are not allowed to review preprints written by close colleagues (with whom they have published in the last four years, with whom they have received joint funding in the last four years, or with whom they are currently writing a manuscript, or submitting a grant proposal), or by family members, friends, or anyone for whom bias might affect the nature of the review - see the code of conduct

Opposed reviewers - Suggest up to 5 people not to invite as reviewers. (Optional)

e.g. John Doe john@doe.com

Submission date

2023-10-17 18:06:38

Recommender

Raquel Assis

Reviewers

or Register
Submit a preprint

MANAGING BOARD

MEMBER OF

INDEXED BY