PCI Math Comp Biol

318

Title *

Phenotype control and elimination of variables in Boolean networksuse asterix (*) to get italics

Authors *

Elisa Tonello, Loïc PaulevéPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year *

2024

Picture *

Abstract *

<p>We investigate how elimination of variables can affect the asymptotic dynamics and phenotype control of Boolean networks. In particular, we look at the impact on minimal trap spaces, and identify a structural condition that guarantees their preservation. We examine the possible effects of variable elimination under three of the most popular approaches to control (attractor-based control, value propagation and control of minimal trap spaces), and under different update schemes (synchronous, asynchronous, generalized asynchronous). We provide some insights on the application of reduction, and an ample inventory of examples and counterexamples.</p>

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Keywords (optional)

Boolean network, phenotype control, reduction, trap spaces

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields *

Dynamical systems, Systems biology

Suggested reviewers - Suggest up to 10 reviewers (provide names and Email addresses). (Optional)

Jorge Gómez Tejeda Zañudo, jgtz@broadinstitute.org, Réka Albert, rza1@psu.edu, David Safranek, xsafran1@fi.muni.cz, Alan Veliz-Cuba, avelizcuba1@udayton.edu, Franck Delaplace, franck.delaplace@ibisc.univ-evry.fr, Georgios Argyris, g.argyris@utwente.nl, Ion Petre, ion.petre@utu.fi, Claudine Chaouiya, claudine.chaouiya@univ-amu.fr

e.g. John Doe john@doe.com

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Submission date

2024-06-05 10:12:39

Recommender

Claudine Chaouiya

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