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The origin of the allometric scaling of lung ventilation in mammalsuse asterix (*) to get italics
Frédérique Noël, Cyril Karamaoun, Jerome A. Dempsey, Benjamin MauroyPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"
2021
<p>A model of optimal control of ventilation has recently been developed for humans. This model highlights the importance of the localization of the transition between a convective and a diffusive transport of respiratory gas. This localization determines how ventilation should be controlled in order to minimize its energetic cost at any metabolic regime. We generalized this model to any mammal, based on the core morphometric characteristics shared by all mammalian lungs and on their allometric scaling from the literature. Since the main energetic costs of ventilation are related to convective transport, we prove that, for all mammals, the localization of the shift from a convective transport to a diffusive transport plays a critical role on keeping this cost low while fulfilling the lung function. Our model predicts for the first time the localization of this transition in order to minimize the energetic cost of ventilation, depending on mammal mass and metabolic regime. From this optimal localization, we are able to predict allometric scaling laws for both tidal volumes and breathing rates, at any metabolic rate. We ran our model for the three common metabolic rates -- basal, field and maximal -- and showed that our predictions reproduce accurately experimental data available in the literature. Our analysis supports the hypothesis that mammals allometric scaling laws of tidal volumes and breathing rates at a given metabolic rate are driven by a few core geometrical characteristics shared by mammalian lungs and by the physical processes of respiratory gas transport.</p>
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https://doi.org/10.5281/zenodo.5112934You should fill this box only if you chose 'Scripts were used to obtain or analyze the results'. URL must start with http:// or https://
https://doi.org/10.5281/zenodo.5112934You should fill this box only if you chose 'Codes have been used in this study'. URL must start with http:// or https://
Allometry, Respiratory system, Gas transport, Metabolic rate, Lung morphometry
NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).
Biophysics, Evolutionary Biology, Physiology
No need for them to be recommenders of PCI Math Comp Biol. Please do not suggest reviewers for whom there might be a conflict of interest. Reviewers are not allowed to review preprints written by close colleagues (with whom they have published in the last four years, with whom they have received joint funding in the last four years, or with whom they are currently writing a manuscript, or submitting a grant proposal), or by family members, friends, or anyone for whom bias might affect the nature of the review - see the code of conduct
e.g. John Doe [john@doe.com]
2020-08-28 15:18:03
Wolfram Liebermeister